Key Stock Information

Relief shares are listed on the SIX Swiss Exchange under the valor symbol RLF and quoted on the U.S. OTCQB Venture under the symbol RLFTF

Share details (SIX)
Valor symbol
Valor number
Regulatory standard
International Reporting Standard
Trading currency
Nominal share value
Registered Share capital (in units)


Authorized capital (in units)
Conditional capital (in units)


Share details (U.S. OTCQB)
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Principal shareholders

Global Emerging Markets (GEM)
Relief founders

Disclosure of Shareholdings

Shareholders who hold shares in a company incorporated in Switzerland whose equity securities are listed in Switzerland have the duty to disclose if they reach, exceed or fall below certain thresholds (3, 5, 10, 15, 20, 25, 33 1/3, 50, 66 2/3 % of voting rights.)

Please inform us in case of exceedance or shortfall of the threshold by post or e-mail (This email address is being protected from spambots. You need JavaScript enabled to view it.) with the official term “Disclosure of Shareholdings”.

The reporting form can be found at this link: 

Financial Calendar

  • Extraordinary General Meeting

    December 17, 2020
  • Interim Financial Statement

    September 15, 2020
  • Annual General Meeting

    By June, 2021
  • Annual Report

    By April 30, 2021

    Shareholder FAQ

    Relief shares are listed on the SIX Swiss Exchange and quoted on the U.S. OTCQB Venture


    What is the Company's mission?

    To provide patients with therapeutic RELIEF from serious diseases with high unmet medical need.

    When was Relief founded?
    RELIEF THERAPEUTICS Holding AG was formed in 2016 by three ex-Merck (Serono division) employees.
    How can I receive the latest corporate news releases? Where are the archived releases located?

    To receive our latest news releases, please register for our corporate newsletter. Once registered, you will receive all corporate news as soon as they are published. Archived press releases can be found here:

    How can I view documents Relief has filed with the SIX swiss exchange?

    To view all documents filed with the SIX Swiss Exchange, please visit the “Notices Market Participants” section of and select RELIEF THERAPEUTICS Holding AG in the Issuer filter.

    When does Relief publish its financial results?

    We publish our half year and annual results in compliance with SIX requirements. Typically, this occurs in April and September of each fiscal year, respectively.



    How is Relief’s stock traded?

    Our shares are listed on the SIX Swiss Exchange under the symbol RLF and are quoted in the U.S. on OTCQB Venture Market under the symbol RLFTF.

    When did Relief go public?

    Relief was formed from a reverse merger with THERAMetrics Holding AG in 2016. THERAMetrics Holding AG (then mondoBIOTECHHolding AG) was listed on the SIX since 2009. Following the business combination, Relief took over the SIX listing.

    Is Relief stock part of a benchmark index?

    Relief stock is included, amongst others, in the Swiss Exchange Swiss Performance Index.

    With effect of November 30, 2020 Relief stock will also be included in the MSCI Global Small Cap Index.

    How many stock options and warrants are outstanding?

    As of October 14, 2020, there were 24,017,658 options and 586,658,667 warrants outstanding.

    What is the remaining size and duration of the SSF program with GEM? Has Relief signed a follow-up contract?

    On September 28, 2020, Relief announced the conclusion of its existing Share Subscription Facility (SSF) with the Company’s main shareholder GEM Global Yield LLC SCS. Relief currently has no plans to put a new SSF in place.

    Does Relief pay dividends?
    The Company is not currently generating revenue; no dividends are being paid.



    What is RLF-100™’s mode-of-action?

    RLF-100™ is a synthetic Vasoactive Intestinal Peptide (VIP) that has a multimodal mechanism of action. It binds to Type 2 alveolar cells (found in the lungs), resulting in a significant modulation of the immune cell response (macrophages, CD4-T cells and tolerogenic dendritic cells) mediated by activation of the VPAC1 and VPAc2 receptors. RLF-100™ thus plays an anti-inflammatory and immunomodulatory role vis-à-vis the immune cells; has vasodilatory and inotropic effects through the vascular system; and helps to maintain the bronchial system by upregulating the production of surfactant in the lungs, preventing cell death.

    When do you expect an FDA-approval with the intravenous and inhaled formulation?

    We cannot speculate on the likelihood or timing of an FDA-approval. We anticipate top-line results from the U.S. Phase 2b/3 trial with the IV formulation of RLF-100™ in January 2021. In September, we submitted a request for an Emergency Use Authorization (EUA) with the FDA for the use of RLF-100™ in patients who are receiving intensive care and who have exhausted all approved treatments. We expect to file a New Drug Application (NDA) with the FDA for full formal approval of RLF-100™ during 2021.

    The U.S. Phase 2b/3 study with the inhaled formulation of RLF-100™ is expected to start enrolling patients in October/November 2020 with top-line data expected in Q2 2021.

    What is the nature of your partnership with NeuroRx?

    On September 21, 2020, Relief and NeuroRx announced the completion of their partnership agreement for the commercialization of RLF-100™ worldwide. The two organizations have agreed to share all profits from sales of RLF-100™ for all indications related to COVID-19 and potentially other respiratory indications on a global basis. They have agreed that NeuroRx will lead commercialization in the United States, Canada, and Israel, while Relief will lead commercialization in Europe and the rest of the world. Profits from sales will be allocated to Relief and NeuroRx on a 50/50 basis in the U.S., Canada and Israel, 85/15 (in favor of Relief) in Europe, and 80/20 (in favor of Relief) in all other territories.

    What is your IP position for RLF-100™?

    Relief holds a patent covering potential formulations of RLF-100™ in the United States valid until at least July 2029, with extension opportunities up to five years as well as in the EU and RoW (Great Britain, Germany, Turkey, Spain, Switzerland, Netherlands, Denmark, Ireland, Austria, PRC and Mexico) valid until at least 2026, excluding extension opportunities comparable to the U.S.

    Are there any other compounds next to RLF-100™ in your pipeline that are already in the clinic?
    Not at this time. However, we are seeking partnerships with companies who have late-stage clinical assets that can be rapidly advanced in order to bring new therapeutic options to the market as quickly as possible.
    When can we expect to receive a response from the FDA to the Emergency Use Authorization (EUA) application filed at the end of September?

    The FDA does not have a specific timeline by which it must respond to an EUA application and so, unfortunately, we are not able to provide further clarity on the timing of an agency response. With this in mind, a response could come before or after top-line data are released from our Phase 2b/3 trial in critically ill COVID-19 patients. Top-line data are currently expected in January 2021.

    Comparisons between RLF-100™ and company products recently granted EUA cannot be drawn. For one, there is no way to determine when a company filed an EUA application unless a company discloses this information, which is not common practice. We did so to provide the utmost of transparency to our investors and stakeholders. It is important to note that the receipt of an EUA by any other company would not exclude RLF-100™ from being granted EUA as well. RLF-100™ in its current trial is used as a therapeutic for the most critical patients. To our knowledge, there is no other drug currently available on the market or in late-stage clinical development that specifically focuses on this patient population.

    When will Relief appoint a CEO?

    Relief’s management team strategy is to maintain a lean internal structure and a series of collaborations with relevant worldwide experts. Our management team works collectively to execute all duties traditionally assigned to a CEO. While Relief has plans to expand the management team, we are firstly focused on building the right team to see RLF-100™ through clinical development. In parallel, we are setting up a team of experts to competently handle all commercial aspects associated with a potential approval, ensuring our therapy reaches patients in need.

    When will the inhaled trial with RLF-100™ commence?

    The Phase 2/3 trial with inhaled RLF-100™ for the treatment of moderate and severe COVID-19 related lung injury [in patients with no evidence of respiratory failure] is being run by our partner NeuroRx Inc. To our knowledge, the trial is expected to start by the end of 2020, with top-line results (based on current enrollment estimates) anticipated in Q2 2021.

    When will RLF-100™ be available in Europe?

    Relief is currently preparing a European Phase 2b/3 study with RLF-100™ in COVID-19 patients. Based on current projections the trial should commence in Q1 2021. However, it is our hope that should positive results be obtained in the U.S. trial, this could expedite the clinical assessment of RLF-100™ in Europe.

    How long will it take the FDA to approve RLF-100™ after top-line data are available?

    Assuming that the trial results are positive, a New Drug Application (NDA) submission requesting marketing approval is planned for Q1 2021. The FDA granted RLF-100™ fast track designation, which, among other things, makes RLF-100™ eligible for Priority Review if relevant criteria are met. Priority Review designation means the FDA’s goal is to take action on an application within 6 months compared to 10 months under standard review. It would be reasonable to expect Priority Review for applications filed under the Coronavirus Treatment Acceleration Program (CTAP). RLF-100™ is part of this program, which was promulgated by the FDA earlier this year in express response to the emergence of the COVID-19 pandemic. Full NDA approval could thus be granted to RLF-100™ for the US market by Q3 2021.

    Regarding the EUA, if this is not granted by the time of the top-line data, we would still not be able to provide further clarity on timing as the FDA does not have a specific timeline to respond to an EUA application.

    How do I contact Relief with additional questions?

    For more information, please contact: This email address is being protected from spambots. You need JavaScript enabled to view it..

    Investor Contact

    For investor inquires contact:

    MC Services AG
    Anne Hennecke / Brittney Sojeva
    Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
    Tel.: +49 (0) 211-529-252-14